Goes Well With	Ideal for
Lanes Xtra Energy	Elderly
Mollers Total Plus	Athletes
Pharmaton Geriatric	Vegetarian Diets

General Info:

TONOTIL® contains a unique composition of amino acids & vitamin B12, which effectively treat the feeling of fatigue & weakness.
TONOTIL® PLUS contains an additional active ingredient, L - Carnitine, which participates in the production of more energy in the body.

• Vitamin B12 and 4 amino acids
• Energy and stimulation
• For periods of growth, recovery or stress
• Suitable for adults and children over 10
• Gluten free, sugar free and iodine free
• Suitable for people with diabetes

 

Description:

Tonotil Plus is a formula with, vitamin B12 and 4 amino acids that helps with fatigue and weakness.

 

Each vial contains powder and a solution for a single dose. In the cap we will find the powder that contains phosphothreonine, glutamine and vitamin B12, while in the vial the solution with phosphoserine, arginine and carnitine.

• Glutamine: plays a very important role in the nervous system and in the synthesis of neurotransmitters (eg acetylcholine) as well as in intestinal health. In fact, it is the amino acid that has been shown in studies to contribute to muscle recovery after long workouts. **
• Arginine: an amino acid that plays a very important role in the synthesis of proteins. Its involvement in the production of NO (nitric oxide-endogenous vasodilator) is the main reason it is often used by athletes, because it results in increased blood flow and a slight decrease in blood pressure. In addition, it can be useful in the process of muscle and tissue repair **
• Vitamin B12: plays a role in the process of cell division and contributes to the normal functioning of metabolic processes aimed at energy production, strengthening the immune system, the functioning of the nervous system, the normal metabolism of homocysteine ​​and the formation of red blood cells, normal and reduce fatigue and tiredness *
• Phosphoserine and phosphothreonine: participate in the synthesis of nucleic acids and most phosphoproteins in the brain. Because they contain phosphorus they are used as an energy source for the body's functions.

 

How to use:

1 vial per day.

Take in the morning before breakfast. It is noted that it can be diluted with water.

Clinical Advice:

It is an effective stimulant product. Even if it is mainly used in elderly, you should always keep in mind  that it can increase the heart rate.

 

Evidence:

Apolzan JW, Stein JA, Rood JC, Beyl RA, Yang S, Greenway FL, Lieberman HR. Effects of acute arginine supplementation on neuroendocrine, metabolic, cardiovascular, and mood outcomes in younger men: A double-blind, placebo-controlled trial. Nutrition. 2022 Sep;101:111658. doi: 10.1016/j.nut.2022.111658. Epub 2022 Mar 20. PMID: 35691183; PMCID: PMC9310054.

Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564. PMID: 30360490; PMCID: PMC6266414.

Blachier F, Blais A, Elango R, Saito K, Shimomura Y, Kadowaki M, Matsumoto H. Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies. Amino Acids. 2021 Sep;53(9):1313-1328. doi: 10.1007/s00726-021-03054-z. Epub 2021 Aug 2. PMID: 34338884; PMCID: PMC8416832.