Larry McCall was signed by the Baltimore Orioles on February 27, 1971 as an amateur free agent. On September 16, 1974, he was purchased by the California Angels from the Baltimore Orioles. On October 25, 1974, he was returned to the Orioles by the Angels. On April 10, 1976, he was released by the Baltimore Orioles, and on the same day, he was signed with the New York Yankees as a free agent.
McCall made his major league baseball debut on September 10, 1977 with the New York Yankees. On that day of his major league debut, the Toronto Blue Jays were playing against the New York Yankees at Yankee Stadiumwith 20,296 people attending the game. At the top of the seventh inning, McCall was called to replace Stan Thomas pitching. He pitched one inning that game. At the top of the eight inning, he was replaced by Ken Holtzman pitching. At the end of the game, the New York Yankees lost the game against the Toronto Blue Jays with the score at 19–4. On November 10, 1978, McCall was traded by the New York Yankees with Mike Heath, Sparky Lyle, Dave Rajsich, Domingo Ramos, and cash to the Texas Rangers for Dave Righetti, Juan Beníquez, Mike Griffin, Paul Mirabella, and minor leaguer Greg Jemison. He played his final Major League Baseball game on September 27, 1979. On January 4, 1980, McCall was traded by the Texas Rangers with Mike Bucci (minors) and Gary Gray to the Cleveland Indians for David Clyde and Jim Norris