Methyl Multi One delivers essential B vitamins like folate, B6 and B12 in their methylated, body-ready forms: 5-MTHF, pyridoxal-5-phosphate (P5P) and methylcobalamin respectively. The body is able to put these vitamins right to work fueling essential methylation activities, rather than having to activate them first. So those with the MTHFR gene mutation, and even those without it, can benefit from getting their daily vitamins with Methyl Multi One! And its gently iron-free formula makes it gentle for continued use!