He attended the School of Visual Arts in Manhattan and graduated with his bachelor of arts in 1977. Today, his works are sold and exhibited in hundreds of galleries and museums in more than twenty different countries around the world. He has been commissioned to create artwork events such as The Super Bowl, The GRAMMY Awards, The Pori Jazz Festival, Major League Baseball All-Star Game, and the Daytime Emmy Awards.
Fazzino is most well known for the three-dimensionality of his silkscreen serigraphs. In 1980, while exhibiting in the juried arts fairs in Florida, Charles Fazzino attended a 3-D paper tole class in an arts supply store. He experimented with the technique and showed his first three-dimensional print at the Greenwich Village Art Show in New York City in May, 1980. Fazzino entered the gallery circuit when he sold his first 3-D offset lithographs to a gallery in Michigan. He began using the silkscreen printing process in 1986