Formulation and Evaluation of Cephalexin Extended Release Tablet

by Hemendra Kumar Sharma, Sandhya Chaurasia, Suneel Kumar Vasireddy

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Description In this study, controlled release matrix tablets containing cephelexin were prepared using HPMC15 cps and Eudragit L100 in different concentration by Direct compression method. Tablets were evaluated for physical properties,Hardness, friability, weight variation and In vitro dissolution study was carried on USP II apparetus (peddle type). The best formulations selected based on above parameters were subjected for Extend release study with use of different ratio of polymer as Eudragit and HPMC .The tablets with Eudragit were found to release drug for longer duration of time as compared to formulations containing HPMC. The drug release from the tablets was sufficiently sustained.

Publisher Description

In this study, controlled release matrix tablets containing cephelexin were prepared using HPMC15 cps and Eudragit L100 in different concentration by Direct compression method. Tablets were evaluated for physical properties, Hardness, friability, weight variation and In vitro dissolution study was carried on USP II apparetus (peddle type). The best formulations selected based on above parameters were subjected for Extend release study with use of different ratio of polymer as Eudragit and HPMC .The tablets with Eudragit were found to release drug for longer duration of time as compared to formulations containing HPMC. The drug release from the tablets was sufficiently sustained.

Author Biography

Mr. Hemendra Kumar Sharma has obtained M. Pharm degree in Pharmaceutical Chemistry in 2011. Since he has published three international and ten national research article in reputed journals in field of analysis and he has also obtained scientific credit from international journal.

Details

  • ISBN 3848432633
  • ISBN-13 9783848432639
  • Title Formulation and Evaluation of Cephalexin Extended Release Tablet
  • Author Hemendra Kumar Sharma, Sandhya Chaurasia, Suneel Kumar Vasireddy
  • Format Paperback
  • Year 2012
  • Pages 144
  • Publisher LAP Lambert Academic Publishing
GE_Item_ID:47057083;

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