Publisher Description

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Back Cover

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Author Biography

Dr. Xiaoting Zhang received his B.S. in Biochemistry and Microbiology from Zhejiang University and M.S. in Genetics from Institute of Genetics, Fudan University, China. He then moved to the United States and received his Ph.D. in Molecular Biology from the University of Iowa, followed by a postdoctoral study at the Rockefeller University. Dr. Zhang's laboratory focuses on understanding the molecular mechanism of estrogen receptor-mediated gene regulation in breast cancer metastasis and therapeutic resistance, and the development of RNA nanotechnology based therapeutics for their treatment. Dr. Zhang has received many awards and grants from major federal, national and local breast cancer funding agencies including NIH/NCI, DoD, American Cancer Society and Komen for the Cure Foundation. He also serves as a regularly invited grant reviewer for all these organizations, as well as international grant organizations such as Hong Kong Research Grant Council, the Marsden Fund of RoyalSociety of New Zealand and American Association for Cancer Research. He is a founding council member and chair of the nomination committee of the International Society of RNA Nanotechnology and Nanomedicine, and a member of the American Association for Cancer Research, American Society for Biochemistry and Molecular Biology and The Endocrine Society.

Table of Contents

1. Introduction: On the discovery of Estrogen Receptor.- 2. Physiological and Pathological Roles of Estrogen Receptor.- 3. Estrogen Receptor Cofactors.- 4. ER-Mediated Gene Transcription.- 5. ER Transcriptome .- 6. Estrogen Receptor Regulation of Non-Coding RNAs in Breast Cancer .- 7. First Targeted Therapy --- History of Tamoxifen.- 8. Selective Estrogen Receptor Modulators (SERMs).- 9. New Estrogen Receptor Drugs.- 10. Endocrine Therapy in Clinical Practice.- 11. Structural Insights into ER and Anti-Estrogen Therapies.- 12. Molecular Mechanisms of Endocrine Resistance.- 13. Estrogen Receptor Mutants in Breast Cancer.- 14. Estrogen Receptor Beta and Isoforms in Breast Cancer.- 15. Xenoestrogens, Phytoestrogens and Breast Cancer.- 16. Emerging Approaches to Overcome Endocrine Resistance.

Long Description

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Feature

Written by World Renowned Leaders of the Estrogen Receptor and Breast Cancer Field to Celebrate the 60th Anniversary of the Discovery of Estrogen Receptor Provides Comprehensive and Most Up-to-Date Information on the History, Recent Advancement and Future Perspective on the Exciting Topics about ER and Breast Cancer Covering Both Basic Sciences and Clinical Practices and Written in a Style Suitable for Readings by Both Advanced Academia and General Audiences

Description for Sales People

--- Written by World Renowned Leaders of the Estrogen Receptor and Breast Cancer Field to Celebrate the 60th Anniversary of the Discovery of Estrogen Receptor --- Provides Comprehensive and Most Up-to-Date Information on the History, Recent Advancement and Future Perspective on the Exciting Topics about ER and Breast Cancer --- Covering Both Basic Sciences and Clinical Practices and Written in a Style Suitable for Readings by Both Advanced Academia and General Audiences.

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