Nathaniel Adams Coles (March 17, 1919 – February 15, 1965), known professionally as Nat King Cole, was an American vocalist and jazz pianist. He recorded over one hundred songs that became hits on the pop charts. His trio was the model for small jazz ensembles that followed. Cole also acted in films and on television and performed on Broadway. He was the first African-American man to host an American television series. He was the father of singer/songwriter Natalie Cole.

In September 1964, Cole began to lose weight and he experienced back pain. Cole collapsed with pain after performing at the Sands Hotel in Las Vegas. In December, he was working in San Francisco when he was finally persuaded by friends to seek medical help. A malignant tumor in an advanced state of growth on his left lung was observed on a chest X-ray. Cole, who had been a heavy cigarette smoker, had lung cancer and was expected to have only months to live. Against his doctors' wishes, Cole carried on his work and made his final recordings December 1–3 in San Francisco, with an orchestra conducted by Ralph Carmichael. The music was released on the album L-O-V-E shortly before his death. His daughter noted later that he did this to assure the welfare of his family.

Cole entered St. John's Hospital in Santa Monica on December 7, and cobalt therapy was started on December 10. Frank Sinatra performed in Cole's place at the grand opening of the new Dorothy Chandler Pavilion of the Los Angeles Music Center on December 12. Cole's condition gradually worsened, but he was released from the hospital over the New Year's period. At home Cole was able to see the hundreds of thousands of cards and letters that had been sent after news of his illness was made public. Cole returned to the hospital in early January. He also sent $5,000 (US$41,218 in 2019 dollars) to chorus girl Gunilla Hutton, with whom he had been romantically involved since early 1964. Hutton later telephoned Maria and implored her to divorce him. Maria confronted her husband, and Cole finally broke off the relationship with Hutton. Cole's illness reconciled him with his wife, and he vowed that if he recovered he would go on television to urge people to stop smoking. On January 25, Cole's entire left lung was surgically removed. His father died of heart problems on February 1. Throughout Cole's illness his publicists promoted the idea that he would soon be well and working, despite the private knowledge of his terminal condition. Billboard magazine reported that "Nat King Cole has successfully come through a serious operation and... the future looks bright for 'the master' to resume his career again." On Valentine's Day, Cole and his wife briefly left St. John's to drive by the sea. He died at the hospital early in the morning of February 15, 1965, aged 45.