Australian comedy which follows the life of Bernadette (Terence Stamp), a middle-aged transgender woman mourning the recent death of her lover. She embarks on a cabaret tour with two drag queen friends, Mitzi (Hugo Weaving) and Felicia (Guy Pearce) and together they set out for a professional engagement in Alice Springs in a gaudily painted bus they name Priscilla. Along the way they encounter various adversely masculine personalities - one of whom, Bob (Bill Hunter), begins to form a romantic attachment to Bernadette.
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