By 1916 Ivogün was reckoned among the best female singers in Europe and had roles in operas such as Fidelio (Marzelline), Così fan tutte, Le nozze di Figaro and many others. Moreover she became well known as Zerbinetta in Richard Strauss’ Ariadne auf Naxos. In 1917 the title of Royal Bavarian Kammersängerin was bestowed upon her. In the same year she sang the boy-role of Ighino in the original production of Hans Pfitzner's Palestrina opposite the tenor Karl Erb in the title-role, whom she married in 1921. In two further important original productions in Munich, Ivogün took on leading roles: in Der Ring des Polykrates of the then barely 19-year-old Erich Wolfgang Korngold (first performance 28 March 1916) she sang Laura, and in Walter Braunfels's Die Vögel (first performance 4 December 1920) she took the part of the Nightingale. In the theatrical season of 1925/1926 Ivogün followed Bruno Walter to the State Opera in Berlin. She remained there as a member of the regular company until 1932.^{[citation needed]}

In 1932, Ivogün divorced Karl Erb, and in 1933 she married their pianist-accompanist Michael Raucheisen. The highly celebrated soprano made countless concert-tours and guest opera appearances both within Germany and beyond. She appeared above all at La Scala, Milan, the Vienna State Opera, Covent Garden, London and the Chicago Opera.