Atlas of Histology of the Juvenile Rat
The definitive resource on the histomorphology of juvenile rats, including input from experienced board-certified toxicologic pathologists who cover organs typically sampled in nonclinical toxicology studies
George A Parker (Edited by), Catherine A. Picut (Edited by)
9780128026823
Hardback, published 27 May 2016
462 pages
27.6 x 21.6 x 2.9 cm, 1.45 kg
"Although this atlas is an essential resource for the toxicological community, it is also relevant for pathologists, veterinarians, and anatomists because of the tremendous detail, precise terminology, and excellent images, along with historical and contemporary references." --Journal of the American Veterinary Medical Association "...an excellent reference to aid the pathologist in both proficiently recognizing distinguishing features of the juvenile rat compared to the adult and identifying possible developmental disturbances. This text will be useful to anyone interpreting pathology endpoints in studies using juvenile rats, whether in industrial or academic research." --Veterinary Pathology
Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.
Integumentary System, Including Mammary and Adnexal Glands Lauren Staska Musculoskeletal System Jairo Nunes Nervous System, Central and Peripheral Amera Remick Respiratory System Melanie Greeley Gastrointestinal System Gary Coleman Liver, Exocrine Pancreas and Salivary Glands Danielle Brown Reproductive System, Female Catherine Picut Reproductive System, Male Catherine Picut Endocrine System Amera Remick Immune System George Parker Hematopoietic System Josely Figuieredo Special Senses (Eye and Ear) Gary Marit Urinary System Danielle Brown Cardiovascular System Melanie Greeley
Subject Areas: Medical toxicology [MMGT]