Soyuz MS-25 is a planned Russian crewed Soyuz spaceflight to launch from Baikonur on 21 March 2024 to the International Space Station.

Crew
American astronaut Tracy Caldwell-Dyson replaced Alexander Grebenkin as a part of the Soyuz-Dragon crew swap system of having at least American and Russian crew member on ISS. This allows continuous space station occupation by US and Russia and keep backup crew scenarios to prevent vehicle grounding like Soyuz MS-10 launch failure or to compensate for delays in launch of crew rotation missions of either vehicles like SpaceX Crew-3 that was delayed due to unfavorable launch weather conditions.

This is the first non-Russian launch of two women astronauts/cosmonauts, Tracy Caldwell-Dyson from US and Marina Vasilevskaya from Belarus, on a Soyuz mission. Notably, the spacecraft commander is retired Russian cosmonaut Oleg Novitsky, born in Chervyen, Minsk Voblast, Byelorussian SSR, USSR (now Belarus).

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