Space Family Robinson was published as a total of 59 issues, from 1962 to 1982. The first issue was published in December 1962. With issue #15 (January, 1966), the "Lost in Space" title was added to the cover. The book Silver Age: The Second Generation of Comic Artists by Daniel Herman explains that when the Lost in Space TV series debuted in 1965, it was obvious that it was inspired, at least in part, by the comic book, but CBS, the network airing the show, had never acquired the license from Western Publishing. Rather than sue CBS or producer Irwin Allen, Western decided to reach a settlement that allowed them to use Lost in Space for the title of the comic book. Since CBS and Irwin Allen licensed shows to Western, Western didn't want to antagonise them.

The title was cancelled with #36 (October, 1969). It was brought back in October, 1973, in part due to the popularity of Star Trek. At this point, all issues between #37 and #44 had the tag "On Space Station One" added as well. The title was cancelled again with #54 (December, 1977) (with #49 being a reprint of #38). In 1981, the title was revived as a reprint title for issues #55–59 (1981–1982) under the "Whitman Comics" line. New stories also appeared in Dell's March of Comics #320, 328, and 352.

The comic was created by writer Del Connell and artist Dan Spiegle. Gaylord Dubois became the sole writer of Space Family Robinson once he began chronicling the Robinsons' adventures with Peril on Planet Four in issue #8. He had already begun the Captain Venture second feature, beginning with Situation Survival in issue #6. As was typical of Gold Key's adventure comics, all cover art was painted, most often by George Wilson.

In the comic, the Robinsons were scientist father Craig, scientist mother June, early teens Tim (son) and Tam (daughter), along with pets Clancy (dog) and Yakker (parrot). They lived in "Space Station One", a spacious moving craft with hydroponic gardens, observatory, and two small "Spacemobile" shuttle craft. The family was selected by computer to be the most mentally and physically qualified to man the space station. They left Earth in the year 2001. In the second issue, a cosmic storm deposited them far from Earth and they have adventures while they try to work their way home.