M. Bijl, G.C.M. Kallenberg
"is a very valuable source for those who want to have an overview of the great progress which has been made in fundamental research, the increasing pathophysiological insights and the current treatment modalities in APS. It is particularly useful for researchers and of value for clinicians dealing with patients with APS and the various disease manifestations these patients can develop." --Annals of the Rheumatic Diseases

This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

Preface. Editor biography. List of Contributors. I. History and Epidemiology of the Antiphospholipid Syndrome (R.A. Asherson). Milestones in the Antiphospholipid Syndrome (R.A. Asherson et al.). Classification and Epidemiology of the Antiphospholipid Syndrome (M. Petri). II. Immunology and Pathophysiology of the Antiphospholipid Syndrome (Y. Shoenfeld). Lupus Anticoagulant: Detection, Standardization and Heterogeneity (D.A. Triplett, M.-C. Boffa). Antibodies to Cardiolipin and other Phospholipids (S.S. Pierangeli, E.N. Harris). &bgr;2-Glycoprotein I and anti-&bgr;2-Glycoprotein I Antibodies (P.G. De Groot et al.). Anti-Prothrombin Antibodies (M. Galli). The Annexins: A Target of Antiphospholipid Antibodies (J.H. Rand, Xiao-Xuan Wu). Antiphospholipid/Endothelial Cell Interaction in the Pathogenesis of the Antiphospholipid Syndrome (P.L. Luigi et al.). Tissue Factor, Protein C pathway and other Hemostasis Abnormalities in the Pathogenesis of the Antiphospholipid Syndrome (R.A.S. Roubey). Systemic Involvement in the Antiphospholipid Syndrome: Lessons from Animal Models (Y. Shoenfeld et al.). Cytokines, Th1/Th2 and Adhesion Molecules in the Antiphospholipid Syndrome (M. Ehrenfeld et al.). Lessons from Monoclonal Antiphospholipid Antibodies (M. Abu-Shakra, Y. Shoenfeld). Immunogenetics of the Antiphospholipid Syndrome (G.D. Sebastiani et al.). Pathology of the Antiphospholipid Syndrome (E. Reyes, D. Alarcón-Segovia). Antiphospholipid Antibodies in Human and Murine Atherogenesis (Y. Sherer, Y. Shoenfeld). III. Clinical Features in the Antiphospholipid Syndrome (R. Cervera).
Thrombotic Manifestations in the Antiphospholipid Syndrome (J.O. Ros et al.). Neurologic Manifestations in the Antiphospholipid Syndrome (R.L. Brey et al.). Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome (G. Espinosa et al.). Renal, Hepatic and other Intra-abdominal Manifestations in the Antiphospholipid Syndrome (P. von Landenberg et al.). Fetal and Obstetric Manifestations and Infertility in the Antiphospholipid Syndrome (F. Carmona, J. Balasch). Osteo articular Manifestations in the Antiphospholipid Syndrome (F. Lioté, O. Meyer). Ophthalmic and Otological Manifestations in the Antiphospholipid Syndrome (A. Montehermoso et al.). Dermatologic Manifestations in the Antiphospholipid Syndrome (C. Frances, J.C. Piette). Endocrine Manifestations in the Antiphospholipid Syndrome (R.A. Asherson, M. Petri). Hematological Abnormalities in the Antiphospholipid Syndrome (G. Espinosa et al.). Immunological Abnormalities in the Antiphospholipid Syndrome (A. Tincani et al.). ''Primary'', ''Secondary'', ''Seronegative'', ''Catastrophic'' and other Subsets of the Antiphospholipid Syndrome (R.A. Asherson et al.). Pediatric and Familial Antiphospholipid Syndrome (L.R. Sammaritano, J.-C. Piette). Antiphospholipid Antibodies and Malignancies (R.A. Asherson et al.). Antiphospholipid Antibodies and Vasculitis (R.A. Asherson, R.A. Levy). Antiphospholipid Antibodies and Infections-Drugs (G. Zandman-Goddard et al.). IV. Management and Prognosis of the Antiphospholipid Syndrome (J.-C. Piette).
Management of Thrombosis in the Antiphospholipid Syndrome (R.H.W.M. Derksen et al.). Management of Reproductive Failure in the Antiphospholipid Syndrome (J. Balasch et al.). Management of the Difficult Aspects of the Antiphospholipid Syndrome (D. Erkan et al.). Course and Prognosis of the Antiphospholipid Syndrome (C. Drenkard, D. Alarcón-Segovia). Novel Perspectives in the Treatment of the Antiphospholipid Syndrome – from Anticoagulation to Immunomodulation (M. Blank et al.). V. Appendix.
The Antiphospholipid Syndrome in the Internet (M. Ramos-Casals, R. Cervera). A Patient´s Guide to the Antiphospholipid Syndrome (J. Berman et al.). Subject Index.

Subject Areas: Immunology [MJCM]