The 2006 Tostitos Fiesta Bowl, played on January 2, 2006, was the 35th edition of the Fiesta Bowl, sponsored by Frito-Lay through its Tostitos tortilla chip brand. The game featured the Notre Dame Fighting Irish and the Ohio State Buckeyes, and resulted in a 34–20 Ohio State win.

Ohio State quarterback Troy Smith became the frontrunner of the 2006 Heisman race, after he completed 19 of his 28 passes for 342 yards, including 2 touchdowns and no interceptions. Notre Dame's Brady Quinncompleted 29 out of his 45 passes for 286 yards.

Notre Dame got the first score of the game, with a 20-yard touchdown run by Darius Walker. Then Ohio State responded on a 6-play, 86-yard drive capped off with a 56-yard touchdown pass to Ted Ginn Jr. In the second quarter, off a wide-receiver reverse, Ginn rushed 68 yards to the left side for a touchdown. Then with just over 2 minutes to go in the half, Troy Smith found Santonio Holmes for an 85-yard touchdown pass, and Ohio State led 21–7 at half-time.

In the second half, Notre Dame scored on Darius Walker's second rushing touchdown of the game, to make the score 21–13 in favor of Ohio State. Notre Dame's defense forced two Ohio State field goals to make the score 27–13. With five minutes left to go in the game, Darius Walker got his third rushing touchdown of the game, bringing the Irish within 27–20. On third and five, with Ohio State using up the clock, the Buckeyes scored on a 60-yard touchdown run by Antonio Pittman to clinch the victory.