Quentin Jacobsen is a high school senior from Florida who is on a mission to find Margo Roth Spiegelman, his enigmatic next door neighbor. She runs away from home just before graduation and Quentin spends the rest of the novel searching for her in hopes of understanding her complicated personality. Along the way, he is accompanied by his friends Radar, Lacey and Ben. They embark on a road trip and make some surprising discoveries.